电话:010-62799141

E-mail address: yatingwang@tsinghua.edu.cn

研究方向
王雅婷课题组的兴趣方向是病原体和免疫系统之间的相互作用。病原微生物感染是对人类健康的持续威胁。我们中的大多数人之所以幸免于这一威胁,是得益于免疫系统的出色工作,在感染性微生物引起症状之前就成功将其消灭。我们实验室的兴趣在于了解免疫系统如何抵抗病原微生物,通过对宿主防御感染的机制进行深入剖析,以期获得新的传染病防治策略。课题组的长期目标是找到抗感染免疫的机制,进而研发疫苗和抗感染药物。目前我们感兴趣的病原微生物包括:结核分枝杆菌,金黄色葡萄球菌,李斯特菌,流感病毒,疱疹病毒等。我们近期研究的侧重是宿主的细胞自噬通路如何调节抗感染免疫。
研究概况

1.Feng, S; McNehlan ME, Kinsella RL, Chowdhury CS, Chavez SM, Naik SK, McKee SR, Van Winkle JA, Dubey N, Samuels A, Swain A, Cui X, Hendrix SV, Woodson R, Kreamalmeyer D, Smirnov A, Artyomov MN, Virgin HW,Wang YT#,Stallings CL#. Autophagy Promotes Efficient T Cell Responses to Restrict High-Dose Mycobacterium Tuberculosis Infection in Mice.Nature Microbiol.2024.

2.Cui X,Wang YT,Function of autophagy genes in innate immune defense against mucosal pathogens.Current Opinion in Microbiology.2024 (invited review)

3.Wang YT, Sansone A, Smirnov A, Stallings CL, Orvedahl A#. Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.Autophagy.2023 Apr;19(4):1114-1127.

4.Wang YT#, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, Pfeifer JD, Baldridge MT, Artyomov MN, Stallings CL#, Virgin HW#. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes.Nature Microbiol.2020 Feb;5(2):272-281. #corresponding author.

5. Strine MS, Fagerberg E, Darcy PW, Barrón GM, Filler RB, Alfajaro MM, D'Angelo-Gavrish N, Wang F, Graziano VR, Menasché BL, Damo M,Wang YT, Howitt MR, Lee S, Joshi NS, Mucida D, Wilen CB. Intestinal tuft cell immune privilege enables norovirus persistence.Science Immunol.2024 Mar 22;9(93):eadi7038.

6. Greene CJ, Nguyen JA, Cheung SM, Arnold CR, Balce, DR,Wang YT,Soderholm A, McKenna N, Aggarwal D, Campden RI, Ewanchuk BW, Virgin HW, Yates RM. Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes.Nat Commun.2022 Jun 2;13(1):3072.

7. Balce DR,Wang YT, McAllaster MR, Dunlap BF., Orvedahl A, Hykes B, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings SL, Virgin HW. UFMylation inhibits the pro-inflammatory capacity of interferon-γ-activated macrophages.Proc Natl Acad Sci USA.2021 Jan 5;118(1):e2011763118.