职称:助理教授,博导

电话:18810462335

E-mail address: sailuo@mail.tsinghua.edu.cn

获奖情况
2021年 第九届Norman L. Letvin青年学者奖
2016年 吴瑞奖学金
工作履历
2023-至今 清华大学医学院基础医学系 助理教授
2021-2023 哈佛大学医学院和波士顿儿童医院 讲师
2017-2021 哈佛大学医学院和波士顿儿童医院 博士后
2011-2016 清华大学生命科学学院 生物学博士
2007-2011 厦门大学生命科学学院 学士
研究方向
病毒疫苗和广谱中和抗体的研究;B细胞受体多样化和等位基因排除的机制研究。目前的研究兴趣包括通过人源化小鼠模型探究病毒感染过程中引发的免疫反应,研究和重塑高突变RNA病毒的广谱中和抗体的产生过程,从而开发新型疫苗和治疗性抗体。同时,进一步研究B细胞受体在发育过程中多样化的产生机制以及可能由非编码RNA介导的等位基因排除的分子机制。
研究概况

1.S. Luo*†,J. Zhang†, A. J. B. Kreutzberger†, A. Eaton, R. J. Edwards, C. Jing, H. Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, L. Vieira Francisco, A. Saminathan, H. Peng, H. Batra, L. Bellusci, S. Khurana, S. M. Alam, D. C. Montefiori, K. O. Saunders, M. Tian, H. Ploegh, T. Kirchhausen*, B. Chen*, B. F. Haynes*, F. W. Alt*, An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.Sci Immunol7, eadd5446 (2022).(*co-corresponding author) (co-first author)

2.S. Luo†,C. Jing†, A. Y. Ye†, S. Kratochvil, C. A. Cottrell, J. Koo, A. C. Williams, L. V. Francisco, H. Batra, E. Lamperti, O. Kalyuzhniy, Y. Zhang, A. Barbieri, J. P. Manis, B. F. Haynes, W. R. Schief, F. D. Batista, M. Tian, F. W. Alt, Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors.Proc Natl Acad Sci,U S A120, e2217883120 (2023)(co-first author)

3.X. Han, J. Zhang, Y. Liu, X. Fan, S. Ai, Y. Luo, X. Li, H. Jin,S. Luo, H. Zheng, Y. Yue, Z. Chang, Z. Yang, F. Tang, A. He, X. Shen, The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2.Development146, (2019).

4.X. Han†,S. Luo†, G. Peng, J. Y. Lu, G. Cui, L. Liu, P. Yan, Y. Yin, W. Liu, R. Wang, J. Zhang, S. Ai, Z. Chang, J. Na, A. He, N. Jing, X. Shen, Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development.J Mol Cell Biol10, 175-178 (2018).(co-first author)

5.S. Luo, J. Y. Lu, L. Liu, Y. Yin, C. Chen, X. Han, B. Wu, R. Xu, W. Liu, P. Yan, W. Shao, Z. Lu, H. Li, J. Na, F. Tang, J. Wang, Y. E. Zhang, X. Shen, Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells.Cell Stem Cell18, 637-652 (2016).

N. Mi, Y. Chen, S. Wang, M. Chen, M. Zhao, G. Yang, M. Ma, Q. Su,S. Luo, J. Shi, J. Xu, Q. Guo, N. Gao, Y. Sun, Z. Chen, L. Yu, CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane.Nat Cell Biol17, 1112-1123 (2015).