专业:分子病毒学

电话:+86-10-62773145

E-mail address: louzy@mail.tsinghua.edu.cn

研究方向
娄智勇博士主要研究高致病性病毒感染和复制、与宿主相互作用过程中的分子机制,以及对病毒生命过程进行调控的手段。
研究概况

(1)A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitorsYan L, Huang Y, Ge J, Liu Z, Lu P, Huang B, Gao S, Wang J, Tan L, Ye S,Yu F, Lan W, Xu S, Zhou F, Shi L, Guddat L. W, Gao Y*, Rao Z*,Lou Z*,Cell2022Nov 10; 185(23): 4347-4360.e17. doi: 10.1016/j.cell.2022.09.037..

(2)Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading. Yan L, Yang Y, Li M, Zhang Y, Zheng L, Ge J, Huang Y, Liu Z, Wang T, Gao S, Zhang R, Huang Y, Guddat LW, Gao Y*, Rao Z*,Lou Z*.Cell. 2021 May24; 184(13): 3474-3485

(3)Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Yan L, Ge J, Zheng L, Zhang Y, Gao Y, Wang T, Huang Y, Yang Y, Gao S, Li M, Liu Z, Wang H, Li Y, Chen Y, Guddat LW, Wang Q, Rao Z*,Lou Z*.Cell. 2020 Nov 14:S0092-8674(20)31533-6. doi: 10.1016/j.cell.2020.11.016.

(4)Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q*,Lou Z*, Rao Z*.Science. 2020 Apr 10. pii: eabb7498. doi: 10.1126/science.abb7498.

(5)DWARF14 is a non-canonical hormone receptor for strigolactone.Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z*,Lou Z*, Xie D*.Nature. 2016 Aug 1. doi: 10.1038/nature19073.

(6)The Life of SARS-CoV-2 Inside Cells: Replication-Transcription Complex Assembly and Function.Lou Z*,Rao Z*,AnnualReview Biochemistry.2022 Jun 21;91:381-401.doi:10.1146/annurev-biochem-052521-115653.

(7)Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation. Wang P, Liu L, Liu A, Yan L, He Y, Shen S, Hu M, Guo Y, Liu H, Liu C, Lu Y, Wang P, Deng F*, Rao Z*,Lou Z*.Nature Microbiology. 2020 Apr 24.

(8)Architecture of a SARS-CoV-2 mini replication and transcription complex. Yan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z*,Lou Z*.Nature Commun.2020 Nov 18;11(1):5874. doi: 10.1038/s41467-020-19770-1.

(9)Divergent engagements between adeno-associated viruses with their cellular receptor AAVR. Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z,Lou Z*.Nature Commun.2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x.

(10)Adeno-associated virus 2 bound to its cellular receptor AAVR. Zhang R, Cao L, Cui M, Sun Z, Hu M, Zhang R, Stuart W, Zhao X, Yang Z, Li X, Sun Y, Li S, Ding W*,Lou Z*, Rao Z.Nature Microbiol.2019 Apr;4(4):675-682. doi: 10.1038/s41564-018-0356-7. Epub 2019 Feb 11.