电话:+86-10-62783887

E-mail address: guanxiangliang@ tsinghua.edu.cn

研究方向
病毒在全球环境中拥有最多的,大约10^ 31的个体数。病毒组一般指某种特定环境下所有病毒的集合,是微生物组的 主要包括能够感染真核细胞的病毒和感染细菌的噬菌体。人类对于能够引起人类或动物疾病的病毒已经进行了数十年 体整体研究一直不够深入。近年来随着相关技术的发展,越来越多的证据显示人类病毒组拥有巨大的多样性和异质性 相关,成为了潜在的致病原因或治疗靶标。 课题组将利用各种生物医学技术,尤其是多组学和生物信息学技术,通过对人类生物样品,模式动物和各种体外实验 病毒组与宿主的关系,并探索其对人类健康的影响。 我们关注病毒组在健康人体的建立与发展过程。我们前期的研究发现了病毒组在人体内的分段定植模式。健康的人类 有病毒,但出生后很快就被细菌寄生。最初阶段定植的病毒主要由最初寄生在肠道的细菌基因组内的原噬菌体诱导释 定植涉及到动物病毒在肠道的寄生,而这一过程中对于噬菌体和动物病毒的定植影响最大的因素是母乳喂养。 我们同样重视病毒组在相关疾病中的作用机制。例如,我们发现炎症性肠病病人肠道内含量最为丰富的两种噬菌体, Microviridae之间比例与疾病严重程度密切相关,相关的噬菌体可能通过与细菌和宿主三方相互作用促进疾病病症。另 新冠病人呼吸道病毒组的分析,发现了可预测疾病严重程度的共生病毒。
研究概况

Liang G,Gao H,Bushman FD The pediatric virome in health and disease.Cell Host Microbe.2022 May11;30(5):639-649.

Liang G,Cobián-Güemes AC,Albenberg L,Bushman FD The gut virome in inflammatory bowel diseases.CurrentOpinion Virology.2021 Dec;51:190-198

Merenstein C,Liang G,Whiteside SA,Cobián-Güemes AG,Merlino MS,Taylor LJ,Glascock A,Bittinger K,TanesC,Graham-Wooten J,Khatib LA,Fitzgerald AS,Reddy S,Baxter AE,Giles JR,Oldridge DA,Meyer NJ,WherryEJ,McGinniss JE,Bushman FD,Collman RG.(2021)Signatures of COVID-19 Severity and Immune Response inthe Respiratory Tract Microbiome.mBio.e0177721.

Bushman F,Liang G.(2021)Assembly of the virome in newborn human infants.Current Opinion Virology.2021Jun;48:17-22.doi:10.1016/j.coviro.2021.03.004.

LiangG,Bushman FD.(2021)The human virome:assembly,composition and host interactions.Nature ReviewMicrobiology.2021 Aug;19(8):514-527.

Liang G,Zhao C,Zhang H,Mattei L,Kessler L,Sherrill-Mix S,Bittinger K,Wu G,Baldassano R,DeRusso P,FordE,Elovitz M,Gerber J,Kelly A,Zemel A,Bushman FD.(2020)Step-wise assembly of the neonatal viromemodulated by breast feeding.Nature 2020 Apr 15;1-5.Z.

Liang G,Conrad M,Kelsen J,Kessler L,Breton J,Albenberg L,Marakos S,Galgano A,Devas N,Erlichman J,Zhang H,Mattei L,Bittinger K,Baldassano R,Bushman FD.(2020)The dynamics of the gut virome in very earlyonset inflammatory bowel disease.Journal of Crohn's and Colitis jjaa094,doi.org/10.1093/ecco-jcc/jaa094

Malmuthuge N,Liang G,Guan LL.(2019)Regulation of rumen development in neonatal ruminants throughmicrobial metagenomes and host transcriptomes.Genome Biology 23;20(1):172.doi:10.1186/s13059-019-1786-0.

Nandi S,Liang G,Sindhava V,Basu A,Zhang Y,Angireddy R,Avadhani N,Atchison ML.(2020)YY1 Control ofMitochondrial-Related Genes does not Account for Regulation of Immunoglobulin Class Switch Recombination.European Journal of Immunology doi.org/10.1002/eji.201948385.

Aggarwala V,Liang G,Bushman FD.(2017)Viral communities of the human gut:metagenomic analysis ofcomposition and dynamics.Mobile DNA 2017 Oct 3;8:12

Liang G,Malmuthuge N,Bao H,Griebel PJ,Stothard P,Guan LL.(2016)Transcriptome analysis reveals regionaland temporal differences in mucosal immune system development in the small intestine of neonatal calves.BMCGenomics doi:10.1186/s128640162957y.

Liang G,Malmuthuge N,Ren Y,Griebel PJ,Guan LL.(2016)Altered microRNA expression and pre-mRNAsplicing events reveal new mechanisms associated with early stage Mycobacterium aviumsubspeciesparatuberculosis infection.Scientific Reports 22;6:24964.doi:10.1038/srep24964.

Liang G,Malmuthuge N,McFadden TB,Bao H,Griebel PJ,Stothard P,Guan LL.(2014)Potential RegulatoryRole of MicroRNAs in the Development of Bovine Gastrointestinal Tract during Early Life.PLoS ONE 9(3):e92592.doi:10.1371/journal.pone.0092592.

Liang G,Malmuthuge N,Guan LL,Griebel PJ (2014)Model systems to analyze the role of miRNAs andcommensal microflora in bovine mucosal immune system development.Molecular Immunologydoi:10.1016/j.molimm.2014.10.014.

请参考:https://pubmed.ncbi.nlm.nih.gov/?term=guanxiang+liang&sort=date