电话:010-62771493

E-mail address: raozh@tsinghua.edu.cn

研究方向
分子生物物理学、病原体结构生物学、新药研发
研究概况

1.Duan, Y.*;Zhou, H.*;Liu, X.*;Iketani, S.*;Lin, M.*;Zhang, X.;Bian, Q.;Wang, H.;Sun, H.;Hong, S. J.;Culbertson, B.;Mohri, H.;Luck, M. I.;Zhu, Y.;Liu, X.;Lu, Y.;Yang, X.;Yang, K.;Sabo, Y.;Chavez, A.;Goff, S.P.;Rao, Z.;Ho, D.D.†;Yang, H.†,Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 2023, 622(7982), 376-382.

2.Yan, L. *; Huang, Y. *; Ge, J. *; Liu, Z. *; Lu, P.; Huang, B.; Gao, S.; Wang, J.; Tan, L.; Ye, S.; Yu, F.; Lan, W.; Xu, S.; Zhou, F.; Shi, L.; Guddat, L. W.; Gao, Y. †;Rao, Z. †; Lou, Z. †, A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors. Cell,2022 Nov 10; 185(23):4347-4360. e17.

3.Lou, Z. †;Rao, Z. †, The Life of SARS-CoV-2 Inside Cells:Replication–Transcription Complex Assembly and Function. Annual Review ofBiochemistry 2022, 91 (1), 381-401. (invited review)

4.Yang, H.†;Rao, Z.†, Structural biology of SARS-CoV-2 and implications for therapeutic development. Nat Rev Microbiol 2021, 19 (11), 685-700.(invited review)

5.Yan, L.*,Yang, Y.*,Li, M.*,Zhang, Y.*,Zheng, L.*; Ge, J.*; Huang, Y. C.*,Liu, Z.*,Wang, T.,Gao, S.,Zhang, R.,Huang, Y. Y.,Guddat, L. W.,Gao, Y.†Rao, Z.†,Lou, Z.†, Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell 2021, 184 (13), 3474-3485 e11.

6.Yan, L.*; Ge, J.*; Zheng, L.*; Zhang, Y.; Gao, Y.; Wang, T.; Huang, Y.; Yang, Y.; Gao, S.; Li, M.; Liu, Z.; Wang, H.; Li, Y.; Chen, Y.; Guddat, L. W.; Wang, Q.;Rao, Z.†; Lou, Z.†, Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. Cell 2021, 184 (1), 184-193 e10.

7.Lv, Z.*; Deng, Y. Q.*; Ye, Q.*; Cao, L.*;Sun, C. Y.*;Fan, C.*;Huang, W.;Sun, S.;Sun, Y.;Zhu, L.;Chen, Q.;Wang, N.;Nie, J.;Cui, Z.;Zhu, D.;Shaw, N.;Li, X. F.;Li, Q.;Xie, L.†;Wang, Y.†;Rao, Z.†;Qin, C. F.†; Wang, X.†, Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. Science 2020, 369 (6510), 1505-1509.

8.Lonhienne, T.*†;Low, Y. S.*;Garcia, M. D.;Croll, T.;Gao, Y.;Wang, Q.;Brillault, L.;Williams, C. M.;Fraser, J. A.;McGeary, R. P.;West, N. P.;Landsberg, M. J.;Rao, Z.;Schenk, G.; Guddat, L. W.†, Structures of fungal and plant acetohydroxyacid synthases. Nature 2020, 586 (7828), 317-321.

9.Wang, Q.*†;Wu, J.*;Wang, H.*;Gao, Y.*;Liu, Q.*;Mu, A.;Ji, W.;Yan, L.;Zhu, Y.;Zhu, C.;Fang, X.;Yang, X.;Huang, Y.;Gao, H.;Liu, F.;Ge, J.;Sun, Q.;Yang, X.;Xu, W.;Liu, Z.;Yang, H.;Lou, Z.;Jiang, B.;Guddat, L. W.;Gong, P.†;Rao, Z.†, Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase. Cell 2020, 182 (2), 417-428 e13.

10.Zhang, L.*;Zhao, Y.*;Gao, Y.;Wu, L.;Gao, R.;Zhang, Q.;Wang, Y.;Wu, C.;Wu, F.;Gurcha, S. S.;Veerapen, N.;Batt, S. M.;Zhao, W.;Qin, L.;Yang, X.;Wang, M.;Zhu, Y.;Zhang, B.;Bi, L.;Zhang, X.;Yang, H.;Guddat, L. W.;Xu, W.;Wang, Q.†;Li, J.†;Besra, G. S.†;Rao, Z.†, Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. Science 2020, 368 (6496), 1211-1219.

11.Dai, W.*;Zhang, B.*;Jiang, X. M.*;Su, H.*;Li, J.;Zhao, Y.;Xie, X.;Jin, Z.;Peng, J.;Liu, F.;Li, C.;Li, Y.;Bai, F.;Wang, H.;Cheng, X.;Cen, X.;Hu, S.;Yang, X.;Wang, J.;Liu, X.;Xiao, G.;Jiang, H.;Rao, Z.;Zhang, L. K.†;Xu, Y.†;Yang, H.†; Liu, H.†, Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science 2020, 368 (6497), 1331-1335.

12.Gao, Y.*;Yan, L.*;Huang, Y.*;Liu, F.*;Zhao, Y.;Cao, L.;Wang, T.;Sun, Q.;Ming, Z.;Zhang, L.;Ge, J.;Zheng, L.;Zhang, Y.;Wang, H.;Zhu, Y.;Zhu, C.;Hu, T.;Hua, T.;Zhang, B.;Yang, X.;Li, J.;Yang, H.;Liu, Z.;Xu, W.;Guddat, L. W.;Wang, Q.†;Lou, Z.†;Rao, Z.†, Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science 2020, 368 (6492), 779-782.

13.Jin, Z.*;Du, X.*;Xu, Y.*;Deng, Y.*;Liu, M.*;Zhao, Y.;Zhang, B.;Li, X.;Zhang, L.;Peng, C.;Duan, Y.;Yu, J.;Wang, L.;Yang, K.;Liu, F.;Jiang, R.;Yang, X.;You, T.;Liu, X.;Yang, X.;Bai, F.;Liu, H.;Liu, X.;Guddat, L. W.;Xu, W.;Xiao, G.;Qin, C.;Shi, Z.;Jiang, H.†;Rao, Z.†; Yang, H.†, Structure of M(pro) from SARS-CoV-2 and discovery of its inhibitors. Nature 2020, 582 (7811), 289-293.

14.Wang, L.*;Wu, J.*;Li, J.*;Yang, H.;Tang, T.;Liang, H.;Zuo, M.;Wang, J.;Liu, H.;Liu, F.;Chen, J.;Liu, Z.;Wang, Y.;Peng, C.;Wu, X.;Zheng, R.;Huang, X.;Ran, Y.;Rao, Z.†; Ge, B.†, Host-mediated ubiquitination of a mycobacterial protein suppresses immunity. Nature 2020, 577 (7792), 682-688.

15.Zhang, S.*;Heyes, D. J.*;Feng, L.*;Sun, W.*;Johannissen, L. O.*;Liu, H.;Levy, C. W.;Li, X.;Yang, J.;Yu, X.;Lin, M.;Hardman, S. J. O.;Hoeven, R.;Sakuma, M.;Hay, S.;Leys, D.;Rao, Z.;Zhou, A.†;Cheng, Q.†; Scrutton, N. S.†, Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature 2019, 574 (7780), 722-725.

16.Wang, N.*;Zhao, D.*;Wang, J.*;Zhang, Y.*;Wang, M.;Gao, Y.;Li, F.;Wang, J.;Bu, Z.†;Rao, Z.†; Wang, X.†, Architecture of African swine fever virus and implications for viral assembly. Science 2019, 366 (6465), 640-644.

17.Zhang, B.*;Li, J.*†;Yang, X.;Wu, L.;Zhang, J.;Yang, Y.;Zhao, Y.;Zhang, L.;Yang, X.;Yang, X.;Cheng, X.;Liu, Z.;Jiang, B.;Jiang, H.;Guddat, L. W.;Yang, H.†;Rao, Z.†, Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell 2019, 176 (3), 636-648 e13.

18.Gong, H.*;Li, J.*;Xu, A.*;Tang, Y.;Ji, W.;Gao, R.;Wang, S.;Yu, L.;Tian, C.;Li, J.;Yen, H. Y.;Man Lam, S.;Shui, G.;Yang, X.;Sun, Y.;Li, X.;Jia, M.;Yang, C.;Jiang, B.;Lou, Z.;Robinson, C. V.;Wong, L. L.;Guddat, L. W.;Sun, F.†;Wang, Q.†;Rao, Z.†, An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science 2018, 362 (6418).

19.Ma, D.*;Wang, Z.;Merrikh, C. N.;Lang, K. S.;Lu, P.;Li, X.;Merrikh, H.;Rao, Z.; Xu, W.†, Crystal structure of a membrane-bound O-acyltransferase. Nature 2018, 562 (7726), 286-290.

20.Yuan, S.*;Wang, J.*;Zhu, D.*;Wang, N.;Gao, Q.;Chen, W.;Tang, H.;Wang, J.†;Zhang, X.†;Liu, H.†;Rao, Z.†; Wang, X.†, Cryo-EM structure of a herpesvirus capsid at 3.1 A. Science 2018, 360 (6384).

21.Yao, R. *;Ming, Z. *;Yan, L. *;Li, S. *;Wang, F.;Ma, S.;Yu, C.;Yang, M.;Chen, L.;Chen, L.;Li, Y.;Yan, C.;Miao, D.;Sun, Z.;Yan, J.;Sun, Y.;Wang, L.;Chu, J.;Fan, S.;He, W.;Deng, H.;Nan, F.;Li, J.;Rao, Z. †;Lou, Z. †; Xie, D. †, DWARF14 is a non-canonical hormone receptor for strigolactone. Nature 2016, 536 (7617), 469-73.

22.Wang, X. *;Ren, J. *;Gao, Q. *;Hu, Z.;Sun, Y.;Li, X.;Rowlands, D. J.;Yin, W.;Wang, J. †;Stuart, D. I. †;Rao, Z. †; Fry, E. E. †, Hepatitis A virus and the origins of picornaviruses. Nature 2015, 517 (7532), 85-88.

23.Yuan, P. *;Bartlam, M. *;Lou, Z. *;Chen, S.;Zhou, J.;He, X.;Lv, Z.;Ge, R.;Li, X.;Deng, T.;Fodor, E.;Rao, Z. †; Liu, Y. †, Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 2009, 458 (7240), 909-13.

24.He, X. *;Zhou, J.;Bartlam, M.;Zhang, R.;Ma, J.;Lou, Z.;Li, X.;Li, J.;Joachimiak, A.;Zeng, Z.;Ge, R.;Rao, Z. †; Liu, Y. †, Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 2008, 454 (7208), 1123-6.

25.Sun, F.*;Huo, X.;Zhai, Y. J.;Wang, A. J.;Xu, J. X.;Su, D.;Bartlam, M.;Rao, Z. H. †, Crystal structure of mitochondrial respiratory membrane protein complex II. Cell 2005, 121 (7), 1043-1057.

26.Rao, Z.;Belyaev, A. S.;Fry, E.;Roy, P.;Jones, I. M.; Stuart, D. I. †, Crystal structure of SIV matrix antigen and implications for virus assembly. Nature 1995, 378 (6558), 743-7.

27.Rao, Z.;Handford, P.;Mayhew, M.;Knott, V.;Brownlee, G. G.; Stuart, D., The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. Cell 1995, 82 (1), 131-41.